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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Usnic acid, Bleomycin
Phytochemical Name Usnic acid (PubChem CID: 5646 )
Anticancer drug Name Bleomycin (PubChem CID: 5360373 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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Combination Pair ID: 503
Ref_1
Pair Name Usnic acid, Bleomycin
Disease Info [ICD-11: 2F94] Ascitic tumor Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation Down-regulation Expression SMAD2 hsa4087
Up-regulation Expression SMAD3 hsa4088
Up-regulation Expression SMAD7 hsa4092
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP8 hsa841
Up-regulation Expression CDKN1A hsa1026
Up-regulation Expression TP53 hsa7157
Down-regulation Expression CCND1 hsa595
Down-regulation Expression CCNE1 hsa898
Down-regulation Expression SOD1 hsa6647
Up-regulation Expression PHEX hsa5251
Up-regulation Expression TNF hsa7124
Up-regulation Expression IL1B hsa3553
Up-regulation Expression IL6 hsa3569
Up-regulation Expression TGFB1 hsa7040
In Vitro Model H22 Hepatocellular carcinoma Mus musculus (Mouse) CVCL_H613
In Vivo Model Mice in Model, BLM, UA and UA + BLM groups were inoculated with H22 cells (0.2 mL, 2×10⁶ cells/mouse, i.p.) to establish malignant ascites tumor-bearing mouse model.
Result Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin
03. Reference
No. Title Href
1 Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin. Int Immunopharmacol. 2017 May;46:146-155. doi: 10.1016/j.intimp.2017.03.004. Click
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